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In a three necked flask equipped with a dropping funnel, a thermometer and a reflux condenser, n-eicosanol (182 g) was dissolved in toluene (1250 ml) in a nitrogen atmosphere. To the solution, p-nitrophenyl isocyanate (100 g) was gradually added, and the mixture was stirred at room temperature for 10 minutes and then heat-refluxed for 30 minutes. When the reaction liquid was cooled to room temperature, crystals precipitated. The crystals were collected by filtering and washed with toluene. n-eicosyl p-nitrophenylcarbamate (270 g) was obtained at a yield of 96%.

1. customIn a three necked flask equipped with a dropping funnel
2. temperatureheat-refluxed for 30 minutes
3. customWhen the reaction liquid
4. temperaturewas cooled to room temperature
5. customcrystals precipitated
6. customThe crystals were collected
7. filtrationby filtering
8. washwashed with toluene