Trimethyl orthoformate → HCID 21226438, compound

HRID 583039Notes

Reaction equation

HRID 583039 reaction equation
O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3].[CH:19]([O:24][CH3:25])([O:22][CH3:23])OC.[Cl:26][C:27]1[C:28]([C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[C:39](C=O)[CH:38]=2)=[N:29][N:30]([CH3:36])[C:31]=1[O:32][CH:33]([F:35])[F:34]>ClCCl>[Cl:26][C:27]1[C:28]([C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([CH:19]([O:22][CH3:23])[O:24][CH3:25])[CH:38]=2)=[N:29][N:30]([CH3:36])[C:31]=1[O:32][CH:33]([F:34])[F:35]

Participants

5

Reactant 3

HCID 9005Trimethyl orthoformateHCID 152201894-Chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazoleHCID 71586775Bentonite

Product 1

HCID 21226438HCID 21226438, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

15 g of montmorillonite K10 were added to a solution of 16 ml of trimethyl orthoformate in 80 ml of dichloromethane. A solution of 6.4 g (20 mmol) of 4-chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 20 ml of dichloromethane was added dropwise at 5° C. to this mixture. The mixture was then stirred at room temperature overnight. The solids were then separated off and the clear reaction solution which remained was concentrated. Yield: 6.7 g.

Workup

  1. customThe solids were then separated off
  2. concentrationthe clear reaction solution which remained was concentrated

Sources & evidence

ORD record
ord-a9ee5250a57242238065ddd1679e7114
Source dataset
uspto-grants-1999_07
Patent number
US05928999

Reaction notes

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