3-Fluorophenylboronic acid → HCID 86650084, compound

HRID 58305Notes

Reaction equation

HRID 58305 reaction equation
[N:1]([CH:4]([C:6]1[N:7]=[C:8]2[S:16][CH:15]=[C:14]([C:17]([F:20])([F:19])[F:18])[N:9]2[C:10](=[O:13])[C:11]=1Br)[CH3:5])=[N+:2]=[N-:3].[F:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1>>[N:1]([CH:4]([C:6]1[N:7]=[C:8]2[S:16][CH:15]=[C:14]([C:17]([F:20])([F:19])[F:18])[N:9]2[C:10](=[O:13])[C:11]=1[C:26]1[CH:25]=[CH:24][CH:23]=[C:22]([F:21])[CH:27]=1)[CH3:5])=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 86650085HCID 86650085, compound

Product 1

HCID 86650084HCID 86650084, compoundYield 29%

Procedure

The desired compound was prepared according to the procedure of Example 8, step 5, using 7-(1-azidoethyl)-6-bromo-3-(trifluoromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one and (3-fluorophenyl)boronic acid as the starting materials in 29% yield. LCMS for C15H10F4N5OS (M+H)+: m/z=383.9.

Sources & evidence

ORD record
ord-8e869fcf9e19423bb430e8e4ffc10f6b
Source dataset
uspto-grants-2016_09
Patent number
US09434746B2

Reaction notes

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