Potassium Hydroxide → HCID 21226463, compound

HRID 583051Notes

Reaction equation

HRID 583051 reaction equation
[OH-].[K+].[Cl:3][C:4]1[C:5]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([N:21](S(C)(=O)=O)[S:22]([CH3:25])(=[O:24])=[O:23])[CH:15]=2)=[N:6][N:7]([CH3:13])[C:8]=1[O:9][CH:10]([F:12])[F:11]>O.CO>[Cl:3][C:4]1[C:5]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([NH:21][S:22]([CH3:25])(=[O:23])=[O:24])[CH:15]=2)=[N:6][N:7]([CH3:13])[C:8]=1[O:9][CH:10]([F:11])[F:12]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 15220191HCID 15220191, compound

Product 1

HCID 21226463HCID 21226463, compoundYield 78.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

0.3 g (4.7 mmol) of potassium hydroxide (dissolved in a little water) was added to a solution of 0.9 g (2.3 mmol) of 4-chloro-3-(4-chloro-3-[di-(methylsulfonyl)-amino]-phenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 30 ml of methanol. The mixture was stirred at room temperature for 18 hours and then concentrated. The residue was taken up in 1N hydrochloric acid and then extracted with ethyl acetate. Drying of the organic phase with magnesium sulfate followed by concentration gave 0.7 g of the target product.

Workup

  1. concentrationconcentrated
  2. extractionextracted with ethyl acetate
  3. dry with materialDrying of the organic phase with magnesium sulfate
  4. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-876060c4bdb340ac8ee827b2151cdd8c
Source dataset
uspto-grants-1999_07
Patent number
US05928999

Reaction notes

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