Sodium Methoxide → HCID 21226464, compound

HRID 583054Notes

Reaction equation

HRID 583054 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[C:6]([C:15]2[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[C:17]([N+]([O-])=O)[CH:16]=2)=[N:7][N:8]([CH3:14])[C:9]=1[O:10][CH:11]([F:13])[F:12]>CO>[Cl:4][C:5]1[C:6]([C:15]2[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[C:17]([O:2][CH3:1])[CH:16]=2)=[N:7][N:8]([CH3:14])[C:9]=1[O:10][CH:11]([F:13])[F:12]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 21226456HCID 21226456, compound

Product 1

HCID 21226464HCID 21226464, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

0.9 ml of a 30% strength by weight solution of sodium methylate in methanol was added to a solution of 1.4 g (4.3 mmol) of 4-chloro-3-(4-cyano-3-nitrophenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 30 ml of methanol. The mixture was stirred at room temperature for 6 hours and then cooled to 0° C. for about 16 h. The solid reaction product was then isolated. Yield: 0.6 g.

Workup

  1. temperaturecooled to 0° C. for about 16 h
  2. customThe solid reaction product
  3. customwas then isolated

Sources & evidence

ORD record
ord-d7f681a31c1e4b6296d5f6a2f36145a3
Source dataset
uspto-grants-1999_07
Patent number
US05928999

Reaction notes

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