7-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole → 6-fluoro-3-(piperidin-4-yl)-1H-indole

HRID 583064Notes

Reaction equation

HRID 583064 reaction equation
F[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[F:17]C1C=CC=C2C=1NC=C2C1CCNCC=1>>[F:17][C:3]1[CH:2]=[C:10]2[C:6]([C:7]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][NH:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 120834537-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleHCID 177771337-Fluoro-3-(piperidin-4-yl)-1H-indole

Product 1

HCID 110960776-fluoro-3-(piperidin-4-yl)-1H-indole

Procedure

Similarly prepared was 4-(7-fluoroindol-3-yl)-piperidine from 4-(7-fluoroindol-3-yl)-1,2,5,6-tetrahydropyridine.

Workup

  1. customSimilarly prepared

Sources & evidence

ORD record
ord-21044b7920624e5ab43a12904350191b
Source dataset
uspto-grants-1999_07
Patent number
US05929072

Reaction notes

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