反应详情

1-(2-Chloroethyl)-3,4-dihydro-3-(1-methylethyl)-6-nitro-1H-2,1,3-benzothiadiazine-2,2-dioxide(1.67 g, 0.005 mol) prepared from 3,4-dihydro-3-(1-methylethyl)-6-nitro-1H-2,1,3-benzothiadiazine-2,2-dioxide (prepared from 4-nitroaniline and isopropyl sulfamoyl chloride by methods described above was dissolved in absolute ethanol (50 ml) and hydrogenated at 60 psi in the presence of 5% palladium on charcoal (0.2 g). After 1 hour and no further hydrogen uptake, the catalyst was filtered, washed with ethanol and the solution evaporated to dryness giving 6-amino-1-(2-chloroethyl)-3,4-dihydro-3-(1-methylethyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide.

1. filtrationno further hydrogen uptake, the catalyst was filtered
2. washwashed with ethanol
3. customthe solution evaporated to dryness