HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 1-({(4r,7s,13s,16r)-7-(2-Amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Atosiban | HCID 5311010 | — |
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-({(4r,7s,13s,16r)-7-(2-Amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide | HCID 68613 | — |
Reaction Steps
dissolving the linear atosiban in an acetonitrile aqueous solution, adjusting the pH value with ammonia water, adding H2O2 for oxidizing, filtering, purifying, and transferring to acetate salt and obtain the atosiban acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434767B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1615649a664c48998d795373db230d60 |
| Source note | uspto-grants-2016_09 |