Potassium Carbonate → HCID 70343314, compound

Participants

Reaction Steps

3-{6-Fluoro-indol-3-yl}-pyrrolidine (500 mg, 2.45 mmol), potassium carbonate (1.04 g, 9.8 mmol), and 1-(2-chloroethyl)-3,4-dihydro-3-(1-methylethyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide (708 mg, 2.45 mmol) were refluxed in water (15 ml) under nitrogen overnight. The solid was dissolved in ethyl acetate(2×100 ml) and washed with brine, dried, filtered and evaporated in vacuo to afford a brown oil. Column chromatography eluting with ethyl acetate gave a yellow solid, 3,4-dihydro-1-{2-[3-(6-fluoroindol-3-yl)-pyrrolidinyl]-1-ethyl}-3-(1-methylethyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide, m.p.50.8-54.4° C.

Provenance & Evidence