Methane → HCID 17760228, compound

Participants

Reaction Steps

The N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-3-methyl-4-nitrobenzamide (2 g) prepared in the previous step, 70 mL of ethanol and 150 mg of 5% palladium over charcoal were placed in a hydrogenation bottle and hydrogenated in a Parr apparatus (50 psia, room temperature) for 3 hours. The reaction mixture was then filtered through celite and the solvent eliminated under reduced pressure yield to the crude product. Separation of the crude product by chromatographic column (1:1 ethyl acetate:hexane) yielded 50 mg of the expected N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-amino-3-methylbenzamide.

Provenance & Evidence