Triethylamine → HCID 86754302, compound

Participants

Reaction Steps

To a cooled solution (ice bath) of 2.6 g (10.15 mmole) of methyl 4-acetamido-3-chloro-5-formylbenzoate in 75 ml of methylene chloride was added 1.16 g (13.87 mmole) of methoxylamine hydrochloride followed by 1.93 mL (13.87 mmole) of triethylamine. The ice bath was removed and the resulting mixture stirred overnight at room temperature. The reaction mixture was then washed with water and dried over anhydrous magnesium sulfate. The solvent was removed using a rotary evaporator, yielding 2.29 g methyl 4-acetamido-3-chloro-5-methoxyimino-methylbenzoate used without further purification in the next step.

Provenance & Evidence