反应详情

In a 5-liter three-necked round-bottomed flask equipped with a reflux condenser, overhead stirrer and nitrogen inlet, was placed 318 g of the previously prepared methyl 3-acetoxymethyl-4-nitrobenzoate and 3.2 l of anhydrous methanol. To the resulting solution was bubbled in 40 g of hydrogen chloride and the resulting mixture was refluxed for 3 hours. After cooling to room temperature the solvent was removed using a rotary evaporator yielding 273 g of methyl 3-hydroxymethyl-4-nitrobenzoate as a yellow solid containing traces of methanol, which was used as such in the next step.

1. customIn a 5-liter three-necked round-bottomed flask equipped with a reflux condenser
2. customTo the resulting solution was bubbled in 40 g of hydrogen chloride
3. temperaturethe resulting mixture was refluxed for 3 hours
4. customwas removed
5. customa rotary evaporator