Benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate → 2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-(2-ethylbutyl)acetamide

HRID 58316Notes

Reaction equation

HRID 58316 reaction equation
C(OC(=O)[NH:10][C:11]1[C:12](=[O:27])[N:13]([CH2:17][C:18]([NH:20][CH2:21][CH:22]([CH2:25][CH3:26])[CH2:23][CH3:24])=[O:19])[CH:14]=[CH:15][CH:16]=1)C1C=CC=CC=1>CO.[Pd]>[NH2:10][C:11]1[C:12](=[O:27])[N:13]([CH2:17][C:18]([NH:20][CH2:21][CH:22]([CH2:25][CH3:26])[CH2:23][CH3:24])=[O:19])[CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 1

HCID 118104219Benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate

Product 1

HCID 899258912-(3-Amino-2-oxopyridin-1(2H)-yl)-N-(2-ethylbutyl)acetamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5.22 g of benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate (2.4, ˜11.2 mmol) are dissolved under nitrogen atmosphere in 60 mL of methanol. To this solution, 500 mg of Pd/C (10%) are added and stirred under hydrogen atmosphere at atmosphere pressure for 2.5 h. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Dark oil is obtained and it is suitable for further processing without further purification.

Workup

  1. customThe catalysis is separated by filtration over silica gel, before the solvent
  2. customis removed in vacuo
  3. customDark oil is obtained
  4. customit is suitable for further processing without further purification

Sources & evidence

ORD record
ord-c2844cdd6f244f44be58884743f0df30
Source dataset
uspto-grants-2016_09
Patent number
US09434763B2

Reaction notes

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