HCID 54505013, compound → HCID 67629093, compound

Participants

Reaction Steps

The title compound was prepared by hydrogenation with H2 in methanol over 20% palladium hydroxide of 6-(4-fluorophenyl)-3-[2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-pyridin-3-yl]-1-oxaspiro[4.4]non-3-ene-7-carboxylic acid methyl ester by the method given in Example 6, Step G. H NMR (400 MHz, CDCl3): δ 7.435(d, J=3 Hz,1H);7.20-7.28(m, 2H); 6.78-6.85(m, 2H); 6.503(d, J=3 Hz, 1H); 4.12(t, J=7 Hz 1H); 3.67 (m, 1H); 3.55(s,3H); 3.53(s, 3H); 3.27-3.45(m, 1H); 3.15-3.20(m,1H); 3.10(t, J=8 Hz, 1H); 2.25-3.33(m, 2H); 2.15-2.24(m, 1H); 1.85-2.0(m, 2H); 1.69(dd, J=13 Hz, J=9 Hz, 1H). Mass spectrum: 522 (M+1).

Provenance & Evidence