HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 583187Generated: October 29, 2026
2-Nitro-4-(trifluoromethyl)phenol → 2-Bromo-6-nitro-4-(trifluoromethyl)phenol
https://huagongshe.com/reaction/583187
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Nitro-4-(trifluoromethyl)phenol | HCID 9816 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-6-nitro-4-(trifluoromethyl)phenol | HCID 21310705 | — |
Reaction Steps
4.0 g of bromine in 7.3 mL of AcOH was added dropwise to a solution of 4.0 g of 2-nitro-4-trifluoromethyl-phenol and 300 mg FeCl3 in 23.1 mL of AcOH at 0° C. Reaction was then heated at 40° C. for 1.5 h. and then allowed to stir for 65 h at rt. Solvent was then removed, placed solid back into EtOAc, filtered through celite and concentrated in vacuo. 5 g of title compound was collected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05929094 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-869dc7ab0e084aa0accb35075140560d |
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| Source note | uspto-grants-1999_07 |
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