Chlorosulfonic acid → HCID 21224947, compound

HRID 583194Notes

Reaction equation

HRID 583194 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]([F:21])([F:20])[C:8]([N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH:11]1[CH3:19])=[O:9]>>[F:21][C:7]([F:6])([F:20])[C:8]([N:10]1[C:18]2[C:13](=[CH:14][C:15]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:16][CH:17]=2)[CH2:12][CH:11]1[CH3:19])=[O:9]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 21224911HCID 21224911, compound

Product 1

HCID 21224947HCID 21224947, compoundYield 7,587.5%

Conditions

Temperature
60 °C

Procedure

Chlorosulfonic acid (25 m, 0.37 mmol) was cooled down to 0° C. in a three necked flask equipped with a thermometer. N-trifluoroacetyl-2-methyl-indoline (17 g, 74.23 mmol) was added thereto in several portions. After the resulting mixture was stirred at 60° C. for 1 hour, the reaction mixture was slowly poured into 200 m of ice water. The precipitate thus formed was collected by filtration and dried to afford 9.2 g of the title compound.

Workup

  1. customequipped with a thermometer
  2. customThe precipitate thus formed
  3. filtrationwas collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-e5fcf3b0d70e43ecbca3c8e8065d790f
Source dataset
uspto-grants-1999_07
Patent number
US05929103

Reaction notes

Loading…