Ethyl isocyanate → HCID 21224892, compound

Participants

Reaction Conditions

Reaction Steps

4-Phenyl-1-(indoline-5-sulfonyl)-2-imidazolone (100 mg, 0.29 mmol) prepared in Preparation 3 was dissolved in 10 m of toluene, and ethylisocyanate (35 μ, 0.435 mmol) was added thereto. The reaction mixture was stirred for 8 hours at 80° C. The solvent was evaporated therefrom under reduced pressure. The residue was dissolved in 30 m of dichloromethane, washed twice with brine, dried over anhydrous magnesium sulfate, concentrated to an oily state, and then purified by silica gel column chromatography (eluent: dichloromethane/methanol=15/1, v/v) to obtain 113 mg of the title compound.

Provenance & Evidence