Pyridine → HCID 21224898, compound

Participants

Reaction Steps

4-Phenyl-1-[N-(4-aminobenzoyl)indoline-5-sulfonyl]-2-imidazolone (150 mg, 0.3 mmol) prepared in Example 10 was dissolved in 10 m of dichloromethane. Pyridine (73 μ, 0.9 mmol) and chloroacetylchloride (36 μ, 0.45 mmol) were added thereto one after another, and then the reaction mixture was stirred at room temperature under nitrogen atmosphere for 2 hours. After stirring, the reaction mixture was diluted with 30 m of dichloromethane, washed with water, dried over anhydrous magnesium sulfate, and then concentrated. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=10/1, v/v) to afford 130 mg of the title compound as a white solid.

Provenance & Evidence