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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 583222Generated: October 25, 2026

Benzylamine → N-(4-[(7-Methoxyheptyl)oxy]butanoyl)-L-isoleucine, ethyl ester

https://huagongshe.com/reaction/583222

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
ReactantL-Isoleucine, ethyl esterHCID 6602175—
Reactant4-[(7-Methoxyheptyl)oxy]butanoyl chlorideHCID 15383030—
Reactant12-Methoxydodecanoyl chlorideHCID 19611759—
ReactantL-isoleucine ethyl ester trifluoroacetateHCID 88304807—
ProductN-(4-[(7-Methoxyheptyl)oxy]butanoyl)-L-isoleucine, ethyl esterHCID 131721076—

Reaction Steps

The title compound is prepared by the method of Example 14 using L-isoleucine ethyl ester trifluoroacetate [the title product of Example 44] as a reactant instead of benzylamine, and using an equivalent amount of 4-[(7-methoxyheptyl)oxy]butanoyl chloride [the title product of Example 100] instead of 12-methoxy-1-docecanoyl chloride [the title product of Example 11].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05929110
Source datasetuspto-grants-1999_07
ORD IDord-238153ed43874c6e931778d9f14a122f
Source noteuspto-grants-1999_07