HCID 21584327, compound → HCID 21584322, compound

HRID 583236Notes

Reaction equation

HRID 583236 reaction equation
[CH2:1]([CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([N+:13]([O-])=O)=[CH:9][CH:10]=2)[CH:5]=[N:4]1)[CH3:2].[ClH:16].C(O)(C)C>CO.[Pd]>[ClH:16].[ClH:16].[CH2:1]([CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([NH2:13])=[CH:9][CH:10]=2)[CH2:5][NH:4]1)[CH3:2]

Participants

5

Reactant 2

HCID 21584327HCID 21584327, compoundHCID 21912024Isopropanol hydrochloride

Product 1

HCID 21584322HCID 21584322, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a pressure bottle charged with 3-ethyl-7-nitro-3,4-dihydroisoquinoline (3.6 g, 17 mmols) dissolved in methanol (100 ml) and saturated isopropanol-HCl (20 ml) was added 10% Pd-C (250 mg), and the reaction hydrogenated for 1 h. The catalyst was removed by filtration and the solvent evaporated to yield 3-ethyl-1,2,3,4-tetrahydroisoquinolin-7-amine dihydrochloride (4.3 g).

Workup

  1. customthe reaction hydrogenated for 1 h
  2. customThe catalyst was removed by filtration
  3. customthe solvent evaporated

Sources & evidence

ORD record
ord-81d480af8274499cad02169952461b42
Source dataset
uspto-grants-1999_07
Patent number
US05929085

Reaction notes

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