HCID 21584276, compound → HCID 21584290, compound

HRID 583254Notes

Reaction equation

HRID 583254 reaction equation
[ClH:1].[CH2:2]([CH:4]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([N+:14]([O-])=O)=[CH:10][CH:11]=2)[CH2:6][N:5]1[CH3:17])[CH3:3].Cl.C(O)(C)C>CO>[ClH:1].[ClH:1].[NH2:14][C:9]1[CH:8]=[C:7]2[C:12]([CH2:13][CH:4]([CH2:2][CH3:3])[N:5]([CH3:17])[CH2:6]2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 21584276HCID 21584276, compoundHCID 21912024Isopropanol hydrochloride

Product 1

HCID 21584290HCID 21584290, compoundYield 192.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a pressure bottle charged with 3-ethyl-2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (3.6 g, 17 mmols) dissolved in methanol (100 ml) and saturated isopropanol-HCl (20 ml) was added 10% Pd--C (250 mg), and the reaction was hydrogenated for 1 h. The catalyst was removed by filtration and the solvent evaporated to give the title compound (4.3 g).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-f930e00b20b54995ba7aeeee1910e2e2
Source dataset
uspto-grants-1999_07
Patent number
US05929085

Reaction notes

Loading…