Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-3-trifluoromethyl-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-Benzyl-N-(2-cyano-6-trifluoromethyl-phenyl)-4-methoxy-benzenesulfonamide | HCID 17866657 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | 2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-3-trifluoromethyl-benzamide | HCID 21310917 | 93% |
반응 단계
To a solution of 1.78 g (4.0 mmol) of the product of Example 122 in 30 mL of n-propanol was added 8 mL of 5N NaOH solution. The resulting mixture was refluxed for 66 h and concentrated. The residue was stirred in water and filtered to provide 1.725 g (93%) of the desired amide as a white solid. Electrospray Mass Spec 465.2(M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05929097 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-276fea84c4bd458293566e0614e945c2 |
| 출처 메모 | uspto-grants-1999_07 |