反应详情

To a suspension of 0.192 g (0.41 mmol) of the product of Example 123 in 2.5 mL of dry CH3CN was added 0.068 g(0.58 mmol) of nitrosonium tetrafluoroborate. The resulting mixture was stirred for 1 h and then added 0.040 g(0.34 mmol) of the same reagent and stirred for additional 1 h. The reaction was quenched with water and filtered to provide 0.141 g (74%) of the desired carboxylic acid as a white solid. Electrospray Mass Spec 466.2(M+H).

1. stirringstirred for additional 1 h
2. customThe reaction was quenched with water
3. filtrationfiltered