(3-Bromopropoxy)(tert-butyl)dimethylsilane → HCID 70198889, compound

HRID 583342Notes

Reaction equation

HRID 583342 reaction equation
[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[N:11]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)(=[O:14])=[O:13].[Si:31]([O:38][CH2:39][CH2:40][CH2:41]Br)([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32]>>[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:41][CH2:40][CH2:39][O:38][Si:31]([C:34]([CH3:35])([CH3:37])[CH3:36])([CH3:32])[CH3:33])[C:5]=1[N:11]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)(=[O:13])=[O:14]

Participants

3

Reactant 2

HCID 607486(3-Bromopropoxy)(tert-butyl)dimethylsilaneHCID 70055074HCID 70055074, compound

Product 1

HCID 70198889HCID 70198889, compoundYield 72.2%

Procedure

In the same manner as described in Example 38, 0.35 g (0.820 mmol) of the product of Example 37 and 0.290 g (1.147 mmol) of 1-t-butyldimethylsilyloxy-3-bromopropane provided 0.355 g (72%) of the desired product as a colorless oil. Electrospray Mass Spec: 600 (M+H).

Sources & evidence

ORD record
ord-e83cf50abc534bb98be026bfd039446f
Source dataset
uspto-grants-1999_07
Patent number
US05929097

Reaction notes

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