HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-[(4-Methoxybenzenesulfonyl)-methylamino]-3-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 3-Bromomethyl-2-[(4-methoxybenzenesulfonyl)-methylamino]-benzoic acid methyl ester | HCID 70053229 | — |
| Product | 2-[(4-Methoxybenzenesulfonyl)-methylamino]-3-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester | HCID 70055416 | 70.4% |
Reaction Steps
In the same manner as described in Example 189, 0.500 g (1.168 mmol) of the product of Example 188 and 0.143 mL (1.285 mmol) of N-methylpiperazine provided 0.368 g (70%) of the desired product as a tan solid. Electrospray Mass Spec: 448.0 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929097 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-3d18731245e84363bcde062621896bc8 |
| Source note | uspto-grants-1999_07 |