HRID583366

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID591073

4-Formylphenylboronic acid

C7H7BO3

结构：COC(=O)c1cc(Br)cc(C)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1

HCID70053864

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cc(-c2ccc(C=O)cc2)cc(C)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1

HCID86754310

未命名化合物

收率 98%

PROCEDURE

实验过程

In the same manner as described in Example 241, 505.4 mg (1.0 mmol) of the product from Example 89 and 165 mg (1.1 mmol) of 4-formylbenzene boronic acid provided 519 mg (98%) of the desired product as a pale yellow solid. Electrospray Mass Spec 531 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d821598feec2460ca2bd7300d7fa6120
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05929097
来源说明: uspto-grants-1999_07

反应 SMILES

[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[C:8](Br)[CH:7]=[C:6]([CH3:11])[C:5]=1[N:12]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1.[CH:32]([C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1)=[O:33]>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[C:8]([C:37]2[CH:38]=[CH:39][C:34]([CH:32]=[O:33])=[CH:35][CH:36]=2)[CH:7]=[C:6]([CH3:11])[C:5]=1[N:12]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1)=[O:31]