(5-Acetylthiophen-2-yl)boronic acid → HCID 70054428, compound

HRID 583369Notes

Reaction equation

HRID 583369 reaction equation
[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[C:8](Br)[CH:7]=[C:6]([CH3:11])[C:5]=1[N:12]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1.[C:32]([C:35]1[S:39][C:38](B(O)O)=[CH:37][CH:36]=1)(=[O:34])[CH3:33]>>[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[C:8]([C:38]2[S:39][C:35]([C:32](=[O:34])[CH3:33])=[CH:36][CH:37]=2)[CH:7]=[C:6]([CH3:11])[C:5]=1[N:12]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 4143377(5-Acetylthiophen-2-yl)boronic acidHCID 70053864HCID 70053864, compound

Product 1

HCID 70054428HCID 70054428, compoundYield 95.3%

Procedure

In the same manner as described in Example 241, 505.4 mg (1.0 mmol) of the product of Example 89 and 374 mg (2.2 mmol) of 5-acetylthiophene-2-boronic acid provided 525 mg (95%) of the desired product as a cream colored solid. Electrospray Mass Spec 551 (M+H).

Sources & evidence

ORD record
ord-fc15af1a15334af48bafc798817feef0
Source dataset
uspto-grants-1999_07
Patent number
US05929097

Reaction notes

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