HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Bromomethyl)thiophene → 3-Formyl-2-[(4-methoxy-benzenesulfonyl)-thiophen-3-ylmethyl-amino]-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Bromomethyl)thiophene | HCID 520703 | — |
| Reactant | 3-Formyl-2-(4-methoxy-benzenesulfonylamino)-benzoic acid methyl ester | HCID 54361995 | — |
| Product | 3-Formyl-2-[(4-methoxy-benzenesulfonyl)-thiophen-3-ylmethyl-amino]-benzoic acid methyl ester | HCID 86754315 | 86% |
Reaction Steps
Following the procedure of Example 322, 1.0 g (2.865 mmol) of the product of Example 321 is reacted with 3-bromomethyl thiophene to give 1.10 g (86%) of the product as a white solid after chromatography on silica gel eluting with EtOAc/Hexanes (1:3). Electrospray Mass Spec: 446.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929097 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-ef55dff1e5284b8284ac9a1fb622984b |
| Source note | uspto-grants-1999_07 |