1-Dodecyne → 5-Dodec-1-ynyl-2-[(4-methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-benzoic acid methyl ester
Reaction equation
[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH3:13][O:14][C:15](=[O:37])[C:16]1[CH:21]=[C:20](Br)[CH:19]=[C:18]([CH3:23])[C:17]=1[N:24]([S:26]([C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)(=[O:28])=[O:27])[CH3:25]>>[CH3:13][O:14][C:15](=[O:37])[C:16]1[CH:21]=[C:20]([C:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:19]=[C:18]([CH3:23])[C:17]=1[N:24]([S:26]([C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)(=[O:28])=[O:27])[CH3:25]Participants
3
Procedure
Following the procedure of Example 351, using 1-dodecyne instead of ethynyl biphenyl, 1.0 g (2.336 mmol) of the product of Example 202 gives 0.874 g (73%) of the alkyne as a brown oil. Electrospray Mass Spec: 514.4 (M+H)+.
Sources & evidence
- ORD record
- ord-4403d977e32043289df75bdc2dd5bd5b
- Source dataset
- uspto-grants-1999_07
- Patent number
- US05929097
Reaction notes
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