2-Methoxybenzylamine → HCID 86754319, compound

Participants

Reaction Steps

This is the compound of Example 3. It can be prepared also by the following synthesis method: a mixture of 0.495 g of 4-[N'-methyl-N'-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(4-chlorophenyl)-pentanoic acid, 0.137 g of 2-methoxy-benzylamine, 0.21 g of N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide hydrochloride, 0.134 g of 4-dimethylaminopyridine and 10 ml of methylene chloride is stirred at room temperature for 16 hours and then concentrated by evaporation. The residue is chromatographed (silica gel, hexane/ethyl acetate 1:1). In this way the title compound is obtained in the form of a colourless amorphous solid. 1H-NMR, 400 MHz, DMSO, 150°, delta (ppm): 7.95(s, 1H), 7.50(s, 2H), 7.43(s, 1H), 7.3-7.1(m, 6H), 6.95(d, 1H), 4.23(d,2H), 3.80(s, 3H), 2.9-2.7(m, 5H), 2.25(m, 2H), 1.92(m, 2H).

Provenance & Evidence