Lithium Hydroxide → HCID 21310527, compound

Participants

Reaction Steps

A solution of 15 g of 4-[N-methyl-N-(3,5-bistrifluoromethyl-benzoyl)-amino]-5(1-methyl-indol-3-yl)-pentanoic acid ethyl ester and 1.78 g of lithium hydroxide in 102.5 ml of tetrahydrofuran/methanol/water =2/2/1 is stirred at room temperature for 3 hours and then concentrated by evaporation. The residue is dissolved in 150 ml of water, extracted with ether, acidified to pH=2 with 0.1N hydrochloric acid and extracted three times with ether. The combined organic phases originating from the extraction of the acidic aqueous phase are washed with water and saturated NaCl solution, dried (magnesium sulfate) and concentrated by evaporation. In this way the title compound is obtained in the form of a yellow foam. Rf value=0.10 (ethyl acetate/hexane 1:1).

Provenance & Evidence