1,2-Dichlorobenzene → HCID 86754325, compound

Participants

Reaction Steps

A solution of 16.82 g of 4-[N-methyl-N-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(1-methyl-indol-3-yl)-pent-2-enoic acid ethyl ester in 170 ml of tetrahydrofuran is hydrogenated for 70 minutes at 20° C. in the presence of 1.7 g of palladium/activated carbon (10%) and 0.2 g of 1,2-dichlorobenzene. The reaction mixture is then filtered and concentrated by evaporation. In this way the title compound is obtained in the form of a brownish-green resin. Rf value=0.265 (ethyl acetate/hexane 2/3).

Provenance & Evidence