Benzoic acid, 2-mercapto-, methyl ester → Methyl 2-[[2-[(4-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]benzoate

Participants

Reaction Steps

This compound was prepared according to the method of Example 132 using a suspension of 0.46 g (1.5 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzene sulfonamide in a mixture of 15 mL of methanol and 15 mL of tetrahydrofuran, and 0.27 g (1.6 mmol) of methyl thiosalicylate. The product was triturated with ether, filtered, washed with ether and dried in vacuo to give 0.66 g of the title compound, mp 288-290° C.

Provenance & Evidence