反应详情

A solution of 0.58 g (2.2 mmol) of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]isothiazol-2-yl)pentanoic acid in 20 mL of methanol was treated with 0.36 g (2.2 mmol) of N-acetyl-L-cysteine and the reaction was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was triturated with 100 mL of 60° C. water. The water was decanted and the solid was dissolved in 50 mL of ethyl acetate. The organic solution was dried (MgSO4), filtered and evaporated in vacuo to give the title compound as a white, solid foam, mp 85-90° C.

1. customThe solvent was removed in vacuo
2. customthe residue was triturated with 100 mL of 60° C. water
3. customThe water was decanted
4. dissolutionthe solid was dissolved in 50 mL of ethyl acetate
5. dry with materialThe organic solution was dried (MgSO4)
6. filtrationfiltered
7. customevaporated in vacuo