反应详情

A suspension of L-lysine (0.931 g, 5.1 mmol) and CuCO3.Cu(OH)2 (1.24 g, 5.6 mmol) in water (15 ml) was heated under reflux for 5 minutes then cooled and filtered. The pH of the filtrate was adjusted to 4 with 2M H2SO4. A solution of sodium nitrite (0.70 g, 10 mmol) in water (5 ml) was added dropwise over 10 minutes and the mixture was strirred at 24° C. for 6 hours. Chelex 100 resin (40 g) was added to effect decomplexation. The resulting suspension was then filtered to give a solution of L-lysine (60%) and (S)-2-amino-6-hydroxyhexanoic acid 2 (30%). ##STR2##

1. temperaturewas heated
2. temperatureunder reflux for 5 minutes
3. temperaturethen cooled
4. filtrationfiltered
5. filtrationThe resulting suspension was then filtered