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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 583621Generated: October 26, 2026

Ibuprofen, (+-)- → Binap, (A+-)-

https://huagongshe.com/reaction/583621

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIbuprofen, (+-)-HCID 3672—
Reactant2-(Acetylamino)-3-phenyl-2-propenoic acidHCID 95631—
Reactant2,2'-Bis{di[p-(3-p-sulfonatophenylpropyl)phenyl]phosphino}-1,1'-binaphthaleneHCID 19347541—
ProductBinap, (A+-)-HCID 634876—

Reaction Steps

According to Example 6, 2-(4-isobutylphenyl) propanoic acid and the methyl ester of acetylaminocinnamic acid were asymmetrically hydrogenated with the Rh- or Ru complexes of (R)-(+)-BINAP-C3 -TS (Table 4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05929273
Source datasetuspto-grants-1999_07
ORD IDord-d969d650eda74cc1b8497eaf1c7c5c94
Source noteuspto-grants-1999_07