HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-Amino-2(S)-phenylsulfonylaminopropionate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2S)-3-amino-2-(benzenesulfonamido)propanoic Acid | HCID 10752796 | — |
| Product | Methyl 3-Amino-2(S)-phenylsulfonylaminopropionate hydrochloride | HCID 22865877 | — |
Reaction Steps
To a stirred solution of 2-1b (5.0 g, 21 mmol) in CH3OH (100 mL) at 0° C. was added SOCl2 (7.5 mL, 100 mmol) dropwise. The cooling bath was then removed and the solution stirred at ambient temperature for 20 h. Concentration and trituration with ether gave 2-2 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-3971192fc39940f886d11dad2ca815a3 |
| Source note | uspto-grants-1999_07 |