HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoate | HCID 18928610 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid | HCID 15850757 | — |
Reaction Steps
A mixture of 3-5 (170 mg, 0.51 mmol), 1N NaOH (5 mL), and CH3OH (10 mL) was stirred at ambient temperature for 20 h. The reaction mixture was cooled to 0° C., neutralized with 1N HCl (5 mL), and then concentrated. The solid was extracted with CHCl3 and the combined extracts concentrated to give 3-6 as a gelatinous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-8a6135e68bf04239aa7cc70c3c5682e9 |
| Source note | uspto-grants-1999_07 |