HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 583664Generated: October 31, 2026
Dimethylformamide → tert-butyl N-(3-hydroxypropyl)carbamate
https://huagongshe.com/reaction/583664
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | tert-butyl N-(3-hydroxypropyl)carbamate | HCID 3838134 | — |
Reaction Steps
To a stirred solution of 3-aminopropanol 8-1 (Aldrich) (15 g, 0.2 mol), NEt3 (42 mL, 0.3 mol) and DMF (400 mL) at 0° C. was added BOC2O (52 g, 0.24 mol). After stirring at 0° C. for 6 h the reaction mixture was diluted with ether and then washed with H2O (2×), sat. NaHCO3, 5% KHSO4 and brine, dried (MgSO4) and concentrated to give 8-2 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05929120 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-ab0e49bfead5406aa9bf2137493ce4f9 |
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| Source note | uspto-grants-1999_07 |
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