(S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochloride → HCID 86752446, compound

HRID 583683Notes

Reaction equation

HRID 583683 reaction equation
[C:1]([NH:8][C@@H:9]([CH3:21])[CH2:10][O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=O)=[CH:14][CH:13]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl.[NH2:23][CH2:24][C@H:25]([NH:33][S:34]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)(=[O:36])=[O:35])[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27]>>[C:29]([O:28][C:26](=[O:27])[C@@H:25]([NH:33][S:34]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)(=[O:36])=[O:35])[CH2:24][NH:23][C:16](=[O:18])[C:15]1[CH:14]=[CH:13][C:12]([O:11][CH2:10][C@@H:9]([NH:8][C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])[CH3:21])=[CH:20][CH:19]=1)([CH3:32])([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 22853534(S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochlorideHCID 22885046HCID 22885046, compound

Product 1

HCID 86752446HCID 86752446, compound

Procedure

Following the procedure for coupling 19-6 to 2-1, 22-4 (295 mg, 1.0 mmol) was coupled to 2-1 (336 mg, 1.0 mmol) to give 22-5 as a beige solid.

Sources & evidence

ORD record
ord-5dc88b3728284d28add00a5f319699b1
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

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