HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → EtOAc EtOH H2O NH4OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-[2-(Thiazol-2-ylamino)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butyl ester | HCID 86752450 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | EtOAc EtOH H2O NH4OH | HCID 86752451 | — |
| Product | 4-[2-(Thiazol-2-ylamino)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine | HCID 86752452 | — |
Reaction Steps
Ester 24-6 (197 mg, 0.36 mmol) was dissolved in 1.8 mL CH2Cl2 and treated with 1.8 mL TFA. Once the starting material had disappeared, the reaction was concentrated, and flash chromatography (silica, 18:10:1:1 EtOAc/EtOH/NH4OH/H2O) provided 24-7 as a white solid. Rf 0.26 (silica, 18:10:1:1 EtOAc/EtOH/NH4OH/H2O).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-be84b9d55e0c4e2d83430b4da88213f6 |
| Source note | uspto-grants-1999_07 |