4-Methylmorpholine → HCID 86752454, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Methylmorpholine	HCID 7972	—
Reactant	Ethyl Acetate	HCID 8857	—
Reactant	Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate	HCID 151348	—
Reactant	Benzoic acid, 4-[2-(2-pyrimidinylamino)ethoxy]-	HCID 10777662	—
Reactant	tert-Butyl 2(S)-Benzyloxycarbonylamino-3-aminopropionate hydrochloride	HCID 22885054	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 86752454	HCID 86752454	—

Reaction Steps

To a stirred solution of 19-6 (400 mg, 1.5 mmol), 25-a (538, 1.6 mmol), DMF (10 mL), and NMM (6.27 mg, 6.0 mmol) at ambient temperature was added BOP reagent (717 mg, 1.6 mmol). After 24 h, the reaction mixture was diluted with EtOAc and then washed with H2O and brine, dried (MgSO4) and concentrated. Flash chromatograpy (silica, 60% EtOAc/hexanes) gave 25-1 as a yellow oil. TLC Rf 0.14 (silica, 60% EtOAc/hexanes);

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05929120
Source dataset	uspto-grants-1999_07
ORD ID	ord-a197989be96e48f5bcdce420eaf1bcda
Source note	uspto-grants-1999_07