1-methyl-1-nitroso-3-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea → Citicoline sodium

HRID 583742Notes

Reaction equation

HRID 583742 reaction equation
[CH3:1][N+:2]([CH2:5][CH2:6][O:7][P:8]([O:11][P:12]([O:15][CH2:16][CH:17]1[O:21][CH:20]([N:22]2[C:27](=[O:28])[N:26]=[C:25]([NH2:29])[CH:24]=[CH:23]2)[C@H:19]([OH:30])[C@@H:18]1[OH:31])([O-:14])=[O:13])([O-:10])=[O:9])([CH3:4])[CH3:3].[Na+:32].CN(N=O)C(N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O)=O>O>[CH3:4][N+:2]([CH2:5][CH2:6][O:7][P:8]([O:11][P:12]([O:15][CH2:16][C@H:17]1[O:21][C@@H:20]([N:22]2[C:27](=[O:28])[N:26]=[C:25]([NH2:29])[CH:24]=[CH:23]2)[C@H:19]([OH:30])[C@@H:18]1[OH:31])([O-:14])=[O:13])([O-:10])=[O:9])([CH3:1])[CH3:3].[Na+:32]

Participants

4

Reactant 2

HCID 27333351-methyl-1-nitroso-3-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]ureaHCID 16211925HCID 16211925, compound

Product 1

HCID 36605Citicoline sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

CDP-choline Na was dissolved in distilled water and orally administered at a dose of 100 mg/kg once a day starting from the time point when 8 weeks passed from the administration of streptozotocin.

Workup

  1. customorally administered at a dose of 100 mg/kg once a day
  2. customstarting from the time point when 8 weeks

Sources & evidence

ORD record
ord-d4925ad469a14c4986675f0f1ee32eae
Source dataset
uspto-grants-2005_08
Patent number
US06924272B2

Reaction notes

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