Benzylamine → 4-(3-Benzyl-ureido)-5-methyl-thiophene-2-carboxylic acid benzylamide

Participants

Reaction Steps

The title compound was prepared according to the procedure described for Example 2 using carbonyldiimidazole (0.24 g, 1.7 mmol), 4-(3-benzyl-ureido)-5-methyl-thiophene-2-carboxylic acid from Step 3 (0.27 g, 0.9 mmol), and benzyl amine (0.1 g, 0.9 mmol) to afford 0.33 g of 4-(3-benzyl-ureido)-5-methyl-thiophene-2-carboxylic acid benzylamide. A sample of the crude product was stirred in 2 M aqueous KHCO3 for several hours, filtered off, rinsed with water, dried, and recrystallized from methanol to give product with a mp 180-181° C.

Provenance & Evidence