1,1'-Carbonyldiimidazole → 5-Methyl-4-nitro-thiophene-2-carboxylic acid (1,3-benzodioxol-5-ylmethyl)-amide

Participants

Reaction Steps

The title compound was prepared according to the procedure described for Example 2 using carbonyldiimidazole (0.7 g, 4.3 mmol), 5-methyl-4-nitro-thiophene-2-carboxylic acid (0.6 g, 3.2 mmol), and piperonyl amine (0.5 g, 3.3 mmol). Acidification of the aqueous workup mixture with dilute hydrochloric acid prior to filtration afforded 1 g of 5-methyl-4-nitro-thiophene-2-carboxylic acid (1,3-benzodioxol-5-ylmethyl)-amide. A sample was dissolved in ethyl acetate and filtered through a short column of silica gel to give 5-methyl-4-nitro-thiophene-2-carboxylic acid (1,3-benzodioxol-5-ylmethyl)-amide; mp 181-183° C.

Provenance & Evidence