Benzyl isocyanate → HCID 10287046, compound

Participants

Reaction Steps

To a solution of the product of Step (d) (0.1 g, 0.000425 mol) in THF (6.07 mL) was added benzyl isocyanate (0.0525 mL, 0.000425 mol), and the mixture was stirred overnight at room temperature. After 24 hours, the mixture was rotary evaporated and the concentrate was diluted with ethyl ether and dichloromethane. A solid was filtered and washed with ethyl ether. The mother filtrate was rotary evaporated and the residue triturated with ethyl ether and dichloromethane to give additional solids. The solids were combined to give 0.12 g of 5-(3-benzyl-ureido)-1,3,4-thiadiazole-2-carboxylic acid benzyl ester; mp 188-192° C.

Provenance & Evidence