HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 131725058, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl 3-aminobenzoate | HCID 11400 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-Ethyl 2-Methyl 6-oxooctahydroisoquinoline-2,3(1H)-dicarboxylate | HCID 14877978 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 131725058 | HCID 131725058 | 92% |
Reaction Steps
Following the procedures from Example 1A, and using ethyl 6-oxo-2-(methoxycarbonyl)-decahydroisoquinoline-3-carboxylate (11.4 g, 40.28 mmol), 3-aminobenzoic acid ethyl ester (3.5 g, 21.2 mmol), glacial acetic acid (5.0 mL, 84.0 mmol), and sodium triacethoxyborohydride (12.58 g, 59.36 mmol) flash chromatography (silica gel, hexane-ethyl acetate 3:1) afforded 8.35 g (92% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06924294B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-dd78bacfe4e14585a13ae8bcb9464390 |
| Source note | uspto-grants-2005_08 |