Benzenesulfonyl chloride → HCID 10029249, compound

Participants

Reaction Steps

Using the general method of Example 242, 1-(8-aminooctyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (1.0 g, 2.72 mmol) was reacted with benzenesulfonyl chloride (350 μL, 2.72 mmol) to provide 1.38 g of N-[8-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)octyl]benzenesulfonamide as an off white powder, m.p. 143-144° C. Analsysis: Calculated for C28H37N5O2S: % C, 66.24; % H, 7.35; % N, 13.79; Found: % C, 66.08; % H, 7.25; % N, 13.72. Karl Fisher titration found 0.23% water.

Provenance & Evidence