反应详情

Carboxylic acid 62 (0.350 g, 2.56 mmol) was suspended in methanol (10 mL). This was cooled in ice and 20% (v/v) thionyl chloride was added portionwise. The solution was stirred in ice for 1 h and then at rt for 18 h before being concentrated in vacuo to afford a white solid, 0.388 g, (100%).

1. temperatureThis was cooled in ice
2. concentrationat rt for 18 h before being concentrated in vacuo
3. customto afford a white solid, 0.388 g, (100%)