Hydrochloric Acid → HCID 22344545, compound

Participants

Reaction Steps

A solution of 2-(3,5-dichloro-4-pyridinyl)-4-(4-iodophenyl)oxazoline (0.2 g, 0.48 mmol), p-ethoxybenzeneboronic acid (0.095 g, 0.57 mmol), sodium carbonate (0.076 g, 0.72 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.025 g) and tri-o-tolylphosphine (0.020 g) was heated at reflux for 12 h under an atmosphere of nitrogen. After cooling, 1N HCl (15 mL) was added and the mixture was extracted with diethyl ether (3×30 mL). The combined ether layers were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by chromatography (eluant, ether/hexane—1:1) to give the product as an off-white solid: mp 121-122° C.

Provenance & Evidence